https://biocomputer.com/tags/variant-effect-prediction/ Recent content in Variant-Effect-Prediction on BIOCOMPUTER Hugo en-us Wed, 08 Apr 2026 00:00:00 +0000 https://biocomputer.com/blog/alphagenome-deepmind-non-coding-genome-crispr/ Wed, 08 Apr 2026 00:00:00 +0000 https://biocomputer.com/blog/alphagenome-deepmind-non-coding-genome-crispr/ <p>On April 7, 2026, Demis Hassabis explained publicly why CRISPR — despite being able to target nearly any DNA sequence — still struggles to cure most genetic diseases: we don&rsquo;t know which mutation is actually driving the problem, especially in the 98% of the genome that doesn&rsquo;t code for proteins.</p> <p>That&rsquo;s the bottleneck. Not the scissors. The map.</p> <p>Enter <strong>AlphaGenome</strong>, DeepMind&rsquo;s new unified DNA sequence model. It takes up to 1 megabase of raw DNA and predicts thousands of functional genomic tracks at single-base-pair resolution — reliably flagging which non-coding variants are likely driving disease. CRISPR just got a targeting system worthy of it.</p>