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    <title>Gene-Therapy on BIOCOMPUTER</title>
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      <title>One Injection Rewrites the Inner Ear&#39;s Code — Hearing Restored in Every Patient</title>
      <link>https://biocomputer.com/blog/otof-gene-therapy-hearing-restored/</link>
      <pubDate>Sun, 05 Apr 2026 00:00:00 +0000</pubDate>
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      <description>&lt;p&gt;In April 2026, a team from Karolinska Institutet and partner hospitals across China injected a synthetic virus carrying a working copy of the &lt;em&gt;OTOF&lt;/em&gt; gene straight into the cochlea of ten patients born deaf. Every single one started hearing again. Average detection threshold dropped from 106 dB to 52 dB. A seven-year-old girl went from profound deafness to holding conversations with her mother in four months.&lt;/p&gt;&#xA;&lt;p&gt;This wasn&amp;rsquo;t a cochlear implant. This wasn&amp;rsquo;t training the brain around the damage. This was a one-shot firmware update to biological hardware that had been running broken code since birth.&lt;/p&gt;&#xA;&lt;p&gt;Biology is now programmable — and the inner ear just proved it at clinical scale.&lt;/p&gt;</description>
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