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    <title>Computational Biology on BIOCOMPUTER</title>
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      <title>All Biology Is Computational Biology — But Now Biology Is the Computer</title>
      <link>https://biocomputer.com/blog/all-biology-is-computational-biology-wetware-era/</link>
      <pubDate>Thu, 09 Apr 2026 00:00:00 +0000</pubDate>
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      <description>&lt;p&gt;In March 2017, Florian Markowetz published a manifesto in &lt;em&gt;PLOS Biology&lt;/em&gt;: all biology is computational biology. He showed how databases, mutational signatures, Next Generation Sequencing alignment, and quantitative maps of tumor heterogeneity turned fuzzy biological ideas into rigorous, testable science. Computation did not just assist biology — it reordered it.&lt;/p&gt;&#xA;&lt;p&gt;Nine years later the thesis stands — and then gets surpassed.&lt;/p&gt;&#xA;&lt;p&gt;We no longer run silicon code &lt;em&gt;about&lt;/em&gt; biology. We grow living processors that &lt;em&gt;are&lt;/em&gt; the code. Biology as computation has completed the inversion. The next modern synthesis is not training biologists to code. It is engineering cells, organoids, and gene circuits that compute natively in chemical space.&lt;/p&gt;</description>
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